Clinical Summaries

Clinical Summary of Walboomers JM et al 1999. Abstract: A recent report that 93 percent of invasive cervical cancers worldwide contain human papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration events affecting the HPV L1 gene, which is the target of the polymerase chain reaction (PCR)-based test which was used. The formerly HPV-negative cases from this study have therefore been reanalyzed for HPV serum antibodies and HPV DNA. Read the Hologic clinical summary document for: Walboomers JM et al 1999. Please visit PubMed for the full abstract.

Clinical Summary of Khan MJ, Castle PE, Lorincz AT et al From April 1, 1989, to November 2, 1990, a total of 20 810 women in the Kaiser Permanente health plan in Portland, OR, enrolled in a cohort study of HPV and cervical neoplasia. Women were tested for 13 oncogenic HPV types by Hybrid Capture 2 (HC2), and those women with a positive HC2 test were tested for HPV16 and 18. Enrollment Pap smear interpretation and HPV test results were linked to histologically confirmed CIN3 and cervical cancer (> or = CIN3) occurring during 10 years of cytologic follow-up. Cumulative incidence rates were calculated with 95% confidence intervals for each interval up to 122 months using Kaplan-Meier methods. Read the Hologic clinical summary for Khan MJ, Castle PE, Lorincz AT et al. Please visit PubMed for the full text article.